Even though Depression is a result of different factors the medicine is not necessarely prescribed and/or made based on that. The anti-depressants may have different ingredients. However, their goal is the same which most of the times is to control two chemical messengers (neurotransmitters) in the brain which are norepinephrine and serotonin.
One of the most prescribed medicine in outpatients to treat major depression is Sertraline commonly known as Zoloft due to its efficacy and less pronounced side effects. Sertraline is an antidepressant from the selective serotonin reuptake inhibitor (SSRI) class, which increases the level of neurotransmitters serotonin. This is also used to control anxiety and personality disorders.
Though there is a controversy between SSRI and Placebo, that compares its effect on mild or moderate depression and major depression, concludes that both of them are better than having not treatment at all.
Another very common class of antidepressants is Serotonin and norepinephrine reuptake inhibitors (SNRIs) which also is used for attention deficit hyperactivity disorder (ADHD), chronic neuropathic pain, fibromyalgia syndrome (FMS), and also helps relieving menopausal symptoms. Different to the SSRIs, this class acts on both Serotonin and norepinephrine not just in Serotonin. One of the most common medications of this class is Cymbalta (duloxetine) which is very effective in elderly, and studies shows that their cognition, pain and depression have improved significantly.
It is also important to mention that all treatments for depression show more results or improvement in patients when the medicine is taken along with therapy.
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